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Twilight sleep in people’s health care

English: Chemical structure of morphine, corre...

English: Chemical structure of morphine, correct 3D configuration. The benzylisoquinoline backbone is shown in blue. (Photo credit: Wikipedia)

The term “twilight sleep” applied to the combination of analgesia (pain  relief) and amnesia (loss of memory) that was produced by a mixture of morphine  and scopolamine (“scope”) given by a hypodermic injection (an injection under  the skin). The mixture of the two drugs created a state in which the woman,  while responding somewhat to pain, did not remember it after delivering her  baby. Twilight sleep was once in vogue in obstetrics.

Morphine and scopolamine are both venerable drugs that have been around a  long time. Both are also naturally occurring members of the very large chemical  class of compounds called alkaloids:

Morphine: The name “morphine” was coined in 1805 by the German  pharmacist Adolf Serturner — “morphine” refers to Morpheus, the mythologic god  of dreams — to designate the main alkaloid contained in opium. Opium, of  course, comes from a plant: the poppy. Morphine is a powerful narcotic agent  with strong analgesic action and other significant effects on the central  nervous system. It is dangerously addicting.  Scopolamine: Scopolamine was introduced in 1902 and used up until the  1960s. The name comes from that of the 18th-century Italian naturalist Giovanni  Scopoli. Together with atropine, scopolamine is a component of belladonna which  comes from a plant called “deadly nightshade,” once used as a means of poisoning  ones enemy. When scopolamine is given in lower (non-poisonous) doses, it causes  drowsiness, amnesia, and euphoria (a “high”) and was thus used as a  preanesthetic agent. Combined with morphine, scopolamine provided childbirth without pain (or  without the memory of pain), once a much sought-after objective. However, there  were serious problems with twilight sleep. It completely removed the mother from  the birth experience and it gravely depressed the baby’s central nervous system.  This sometimes made for a drowsy depressed baby who was difficult to resusitate,  to get breathing normally.

Twilight sleep has, therefore, fallen entirely out of favor and is now merely  a chapter in the past history of obstetrics.

For more information visit: Melatrol website.

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Insomnia from Wellbutrin

bupropion and insomniaInsomnia occurs in 18.6% of patients who take bupropion (Wellbutrin). Bupropion is a detoxification agent and an antidepressant. It regulates the brains in the amount of noradrenaline (norepinephrine), and dopamine. These endogenous substances involved in emotions and moods. Two percent of patients discontinue bupropion because of insomnia and agitation. Interestingly, 19.8% of patients experience sedation instead of insomnia. Decreasing the dose, adding a sedative drug or switching to a different antidepressant may alleviate the problem. For more information visit:  Melatrol official website.


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